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1-[3,5-Bis(trifluoro-meth-yl)phen-yl]-3-[(5-ethenyl-1-aza-bicyclo-[2.2.2]octan-2-yl)(6-methoxy-quinolin-4-yl)meth-yl]thio-urea-l-proline-methanol (1/1/1).

ABSTRACT: In the methanol solvate of the title 1:1 cocrystal, C(29)H(28)F(6)N(4)OS·C(5)H(9)NO(2)·CH(4)O, the l-proline mol-ecule exists as a zwitterion. In the crystal, the disubstituted thio-urea, l-proline and methanol mol-ecules are linked by N-H?O and N-H?N hydrogen bonds, forming a two-dimensional array in the ab plane.

SUBMITTER: Muramulla S

PROVIDER: S-EPMC2972067 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature

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1-[3,5-Bis(trifluoro-meth-yl)phen-yl]-3-[(5-ethenyl-1-aza-bicyclo-[2.2.2]octan-2-yl)(6-methoxy-quinolin-4-yl)meth-yl]thio-urea-l-proline-methanol (1/1/1).

Muramulla Savitha S Arman Hadi D HD Zhao Cong-Gui CG Tiekink Edward R T ER

Acta crystallographica. Section E, Structure reports online 20091114 Pt 12

In the methanol solvate of the title 1:1 cocrystal, C(29)H(28)F(6)N(4)OS·C(5)H(9)NO(2)·CH(4)O, the l-proline mol-ecule exists as a zwitterion. In the crystal, the disubstituted thio-urea, l-proline and methanol mol-ecules are linked by N-H⋯O and N-H⋯N hydrogen bonds, forming a two-dimensional array in the ab plane. ...[more]

PMID: 21578800

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