Ontology highlight
ABSTRACT:
SUBMITTER: Bassani-Sternberg M
PROVIDER: S-EPMC2973870 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Bassani-Sternberg Michal M Barnea Eilon E Beer Ilan I Avivi Irit I Katz Tami T Admon Arie A
Proceedings of the National Academy of Sciences of the United States of America 20101025 44
The HLA molecules are membrane-bound transporters that carry peptides from the cytoplasm to the cell surface for surveillance by circulating T lymphocytes. Although low levels of soluble HLA molecules (sHLA) are normally released into the blood, many types of tumor cells release larger amounts of these sHLA molecules, presumably to counter immune surveillance by T cells. Here we demonstrate that these sHLA molecules are still bound with their authentic peptide repertoires, similar to those of th ...[more]