Evaluation of the association between the AC3 genetic polymorphisms and obesity in a Chinese Han population.

ABSTRACT: BACKGROUND: AC3 is one of adenylyl cyclase isoforms involved in cAMP and insulin signaling pathway. Recent reports have demonstrated that the AC3 genetic polymorphisms are associated with obesity in a Swedish population. AC3 knock out mice exhibit obese when they age. These findings suggest that AC3 plays an important role in the regulation of body weight. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, we evaluated the association between the AC3 genetic polymorphisms and obesity in a Han Chinese population. A total of 2580 adults, including 1490 lean (BMI?=?18.5-23.9), 677 overweight (BMI 24.0-27.9) and 413 obese (BMI ?28.0) subjects were genotyped for 5 TagSNPs in the AC3 gene. Single maker association analyses indicated that SNP rs753529 was significantly associated with BMI in obese subjects (P?=?0.022, OR?=?0.775 95%CI?=?0.623-0.963), but not in overweight subjects (P?=?0.818). Multiple maker association analyses showed that the haplotype (G-G-G) constructed with SNPs rs1127568, rs7604576 and rs753529 was significantly associated with obesity (P?=?0.029). Further genotyping of SNP rs753529 in 816 children, including 361 overweight subjects (BMI>P(80)) and 455 controls (BMI?=?P(20-50)) were performed, and no significant association with BMI was found. All tests were adjusted for age, sex, physical activity index, household income and/or diet expenses. CONCLUSIONS: The present study provides replication evidence that the AC3 genetic polymorphisms are associated with decreased risk of obesity among adults but not in children in a Chinese Han population. The data also suggest that the AC3 genetic effects on BMI may have interaction with the factors related to ageing and environment.

SUBMITTER: Wang H 

PROVIDER: S-EPMC2973974 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature