Down-regulation of serum/glucocorticoid regulated kinase 1 in colorectal tumours is largely independent of promoter hypermethylation.
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ABSTRACT:
SUBMITTER: Lessi F
PROVIDER: S-EPMC2974649 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
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Down-regulation of serum/glucocorticoid regulated kinase 1 in colorectal tumours is largely independent of promoter hypermethylation.
Lessi Francesca F Beggs Andrew A de Palo Mariagrazia M Anti Marcello M Macarone Palmieri Raffaele R Francesconi Simona S Gomes Vito V Bevilacqua Generoso G Tomlinson Ian I Segditsas Stefania S
PloS one 20101105 11
<h4>Background</h4>We have previously shown that serum/glucocorticoid regulated kinase 1 (SGK1) is down-regulated in colorectal cancers (CRC) with respect to normal tissue. As hyper-methylation of promoter regions is a well-known mechanism of gene silencing in cancer, we tested whether the SGK1 promoter region was methylated in colonic tumour samples.<h4>Methodology/principal findings</h4>We investigated the methylation profile of the two CpG islands present in the promoter region of SGK1 in a p ...[more]
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