Serum and Glucocorticoid Regulated Kinase 1 in Sodium Homeostasis.

ABSTRACT: The ubiquitously expressed serum and glucocorticoid regulated kinase 1 (SGK1) is tightly regulated by osmotic and hormonal signals, including glucocorticoids and mineralocorticoids. Recently, SGK1 has been implicated as a signal hub for the regulation of sodium transport. SGK1 modulates the activities of multiple ion channels and carriers, such as epithelial sodium channel (ENaC), voltage-gated sodium channel (Nav1.5), sodium hydrogen exchangers 1 and 3 (NHE1 and NHE3), sodium-chloride symporter (NCC), and sodium-potassium-chloride cotransporter 2 (NKCC2); as well as the sodium-potassium adenosine triphosphatase (Na?/K?-ATPase) and type A natriuretic peptide receptor (NPR-A). Accordingly, SGK1 is implicated in the physiology and pathophysiology of Na? homeostasis. Here, we focus particularly on recent findings of SGK1's involvement in Na? transport in renal sodium reabsorption, hormone-stimulated salt appetite and fluid balance and discuss the abnormal SGK1-mediated Na? reabsorption in hypertension, heart disease, edema with diabetes, and embryo implantation failure.

SUBMITTER: Lou Y 

PROVIDER: S-EPMC5000704 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature