Circular logic: nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst.
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ABSTRACT:
SUBMITTER: McIntosh JA
PROVIDER: S-EPMC2975588 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Publications
Circular logic: nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst.
McIntosh John A JA Robertson Charles R CR Agarwal Vinayak V Nair Satish K SK Bulaj Grzegorz W GW Schmidt Eric W EW
Journal of the American Chemical Society 20101101 44
A protease from ribosomal peptide biosynthesis macrocyclizes diverse substrates, including those resembling nonribosomal peptide and hybrid polyketide-peptide products. The proposed mechanism is analogous to thioesterase-catalyzed chemistry, but the substrates are amide bonds rather than thioesters. ...[more]
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