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Circular logic: nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst.

ABSTRACT: A protease from ribosomal peptide biosynthesis macrocyclizes diverse substrates, including those resembling nonribosomal peptide and hybrid polyketide-peptide products. The proposed mechanism is analogous to thioesterase-catalyzed chemistry, but the substrates are amide bonds rather than thioesters.

SUBMITTER: McIntosh JA

PROVIDER: S-EPMC2975588 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature

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Circular logic: nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst.

McIntosh John A JA Robertson Charles R CR Agarwal Vinayak V Nair Satish K SK Bulaj Grzegorz W GW Schmidt Eric W EW

Journal of the American Chemical Society 20101101 44

A protease from ribosomal peptide biosynthesis macrocyclizes diverse substrates, including those resembling nonribosomal peptide and hybrid polyketide-peptide products. The proposed mechanism is analogous to thioesterase-catalyzed chemistry, but the substrates are amide bonds rather than thioesters. ...[more]

PMID: 20961047

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