Ontology highlight
ABSTRACT:
SUBMITTER: Haywood J
PROVIDER: S-EPMC5834244 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Haywood Joel J Schmidberger Jason W JW James Amy M AM Nonis Samuel G SG Sukhoverkov Kirill V KV Elias Mikael M Bond Charles S CS Mylne Joshua S JS
eLife 20180131
Constrained, cyclic peptides encoded by plant genes represent a new generation of drug leads. Evolution has repeatedly recruited the Cys-protease asparaginyl endopeptidase (AEP) to perform their head-to-tail ligation. These macrocyclization reactions use the substrates amino terminus instead of water to deacylate, so a peptide bond is formed. How solvent-exposed plant AEPs macrocyclize is poorly understood. Here we present the crystal structure of an active plant AEP from the common sunflower, < ...[more]