Hare TRIM5? restricts divergent retroviruses and exhibits significant sequence variation from closely related lagomorpha TRIM5 genes.
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ABSTRACT:
SUBMITTER: Fletcher AJ
PROVIDER: S-EPMC2976397 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
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Hare TRIM5α restricts divergent retroviruses and exhibits significant sequence variation from closely related lagomorpha TRIM5 genes.
Fletcher Adam J AJ Hué Stéphane S Schaller Torsten T Pillay Deenan D Towers Greg J GJ
Journal of virology 20100922 23
TRIM5α proteins recruit and restrict incoming cytoplasmic retroviruses. Primate TRIM5α sequence diversity underlies species-specific restriction and is likely caused by selective pressure from ancient pathogenic infections. Here we show that TRIM5α from the European brown hare restricts diverse retroviruses. Furthermore, it differs significantly in sequence from TRIM5α from the closely related rabbit, suggesting evolutionary changes in the last 12 million years since these species diverged. We p ...[more]
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