Ontology highlight
ABSTRACT:
SUBMITTER: Weng MW
PROVIDER: S-EPMC2978355 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Weng Mao-wen MW Zheng Yi Y Jasti Vijay P VP Champeil Elise E Tomasz Maria M Wang Yinsheng Y Basu Ashis K AK Tang Moon-shong MS
Nucleic acids research 20100706 20
Mitomycin C induces both MC-mono-dG and cross-linked dG-adducts in vivo. Interstrand cross-linked (ICL) dG-MC-dG-DNA adducts can prevent strand separation. In Escherichia coli cells, UvrABC repairs ICL lesions that cause DNA bending. The mechanisms and consequences of NER of ICL dG-MC-dG lesions that do not induce DNA bending remain unclear. Using DNA fragments containing a MC-mono-dG or an ICL dG-MC-dG adduct, we found (i) UvrABC incises only at the strand containing MC-mono-dG adducts; (ii) Uv ...[more]