Ontology highlight
ABSTRACT:
SUBMITTER: Reynolds TE
PROVIDER: S-EPMC2987273 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Organic letters 20070601 13
Highly substituted alpha,beta-unsaturated ketones are prepared by the N-heterocyclic carbene-initiated addition of alpha-hydroxypropargylsilanes to aldehydes. This strategy serves as a highly efficient alternative to the standard Morita-Baylis-Hillman (MBH) approaches for these types of compounds. In contrast to the MBH reaction, different substitution in the beta-position of the product (R1) can be accommodated in moderate to excellent yields with a high degree of control over the resulting alk ...[more]