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General approach to epipolythiodiketopiperazine alkaloids: total synthesis of (+)-chaetocins A and C and (+)-12,12'-dideoxychetracin A.

ABSTRACT: A highly stereoselective and systematic strategy for the introduction of polysulfides in the synthesis of epipolythiodiketopiperazines is described. We report the first total synthesis of dimeric epitri- and epitetrathiodiketopiperazines.

SUBMITTER: Kim J

PROVIDER: S-EPMC2987664 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

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General approach to epipolythiodiketopiperazine alkaloids: total synthesis of (+)-chaetocins A and C and (+)-12,12'-dideoxychetracin A.

Kim Justin J Movassaghi Mohammad M

Journal of the American Chemical Society 20101001 41

A highly stereoselective and systematic strategy for the introduction of polysulfides in the synthesis of epipolythiodiketopiperazines is described. We report the first total synthesis of dimeric epitri- and epitetrathiodiketopiperazines. ...[more]

PMID: 20866039

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