Ontology highlight
ABSTRACT:
SUBMITTER: Robinson MD
PROVIDER: S-EPMC2989998 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Robinson Mark D MD Stirzaker Clare C Statham Aaron L AL Coolen Marcel W MW Song Jenny Z JZ Nair Shalima S SS Strbenac Dario D Speed Terence P TP Clark Susan J SJ
Genome research 20101102 12
DNA methylation is an essential epigenetic modification that plays a key role associated with the regulation of gene expression during differentiation, but in disease states such as cancer, the DNA methylation landscape is often deregulated. There are now numerous technologies available to interrogate the DNA methylation status of CpG sites in a targeted or genome-wide fashion, but each method, due to intrinsic biases, potentially interrogates different fractions of the genome. In this study, we ...[more]