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New templates for HIV-1 antibody-based vaccine design.

ABSTRACT: A current strategy for the design of neutralizing antibody-based vaccines to prevent HIV-1 transmission is that of reverse engineering, starting from a neutralizing antibody and working back to reconstruct its epitope by structure-based design technology. However, the field has been impeded by a lack of appropriate antibodies for use as templates. Recently, new antibodies have been described that may fulfil this role, invigorating the field.

SUBMITTER: Sattentau QJ

PROVIDER: S-EPMC2990654 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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New templates for HIV-1 antibody-based vaccine design.

Sattentau Quentin J QJ McMichael Andrew J AJ

F1000 biology reports 20100809

A current strategy for the design of neutralizing antibody-based vaccines to prevent HIV-1 transmission is that of reverse engineering, starting from a neutralizing antibody and working back to reconstruct its epitope by structure-based design technology. However, the field has been impeded by a lack of appropriate antibodies for use as templates. Recently, new antibodies have been described that may fulfil this role, invigorating the field. ...[more]

PMID: 21173880

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