Ontology highlight
ABSTRACT:
SUBMITTER: Kong L
PROVIDER: S-EPMC3515071 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Journal of AIDS & clinical research 20120322
Neutralizing antibodies can protect from infection by immunodeficiency viruses. However, the induction by active vaccination of antibodies that can potently neutralize a broad range of circulating virus strains is a goal not yet achieved, despite more than 2 decades of research. Here we review progress made in the field, from early empirical studies to today's rational structure-based vaccine antigen design. We discuss the existence of broadly neutralizing antibodies, their implications for epit ...[more]