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Functional identification of neuroprotective molecules.

ABSTRACT: The central nervous system has the capacity to activate profound neuroprotection following sub-lethal stress in a process termed preconditioning. To gain insight into this potent survival response we developed a functional cloning strategy that identified 31 putative neuroprotective genes of which 28 were confirmed to provide protection against oxygen-glucose deprivation (OGD) or excitotoxic exposure to N-methyl-D-aspartate (NMDA) in primary rat cortical neurons. These results reveal that the brain possesses a wide and diverse repertoire of neuroprotective genes. Further characterization of these and other protective signals could provide new treatment opportunities for neurological injury from ischemia or neurodegenerative disease.

SUBMITTER: Dai C

PROVIDER: S-EPMC2991347 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature

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Functional identification of neuroprotective molecules.

Dai Cheng C Liang Dong D Li Huiwu H Sasaki Masayuki M Dawson Ted M TM Dawson Valina L VL

PloS one 20101124 11

The central nervous system has the capacity to activate profound neuroprotection following sub-lethal stress in a process termed preconditioning. To gain insight into this potent survival response we developed a functional cloning strategy that identified 31 putative neuroprotective genes of which 28 were confirmed to provide protection against oxygen-glucose deprivation (OGD) or excitotoxic exposure to N-methyl-D-aspartate (NMDA) in primary rat cortical neurons. These results reveal that the br ...[more]

PMID: 21124846

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