Ontology highlight
ABSTRACT:
SUBMITTER: Sauzeau V
PROVIDER: S-EPMC2993752 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Sauzeau Vincent V Horta-Junior José A C JA Riolobos Adelaida S AS Fernández Gloria G Sevilla María A MA López Dolores E DE Montero María J MJ Rico Beatriz B Bustelo Xosé R XR
Molecular biology of the cell 20101006 23
Vav3 is a phosphorylation-dependent activator of Rho/Rac GTPases that has been implicated in hematopoietic, bone, cerebellar, and cardiovascular roles. Consistent with the latter function, Vav3-deficient mice develop hypertension, tachycardia, and renocardiovascular dysfunctions. The cause of those defects remains unknown as yet. Here, we show that Vav3 is expressed in GABAegic neurons of the ventrolateral medulla (VLM), a brainstem area that modulates respiratory rates and, via sympathetic effe ...[more]