Ontology highlight
ABSTRACT:
SUBMITTER: Cheloufi S
PROVIDER: S-EPMC2995450 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Nature 20100601 7298
The nucleolytic activity of animal Argonaute proteins is deeply conserved, despite its having no obvious role in microRNA-directed gene regulation. In mice, Ago2 (also known as Eif2c2) is uniquely required for viability, and only this family member retains catalytic competence. To investigate the evolutionary pressure to conserve Argonaute enzymatic activity, we engineered a mouse with catalytically inactive Ago2 alleles. Homozygous mutants died shortly after birth with an obvious anaemia. Exami ...[more]