Ontology highlight
ABSTRACT:
SUBMITTER: Pullagura SRN
PROVIDER: S-EPMC5887145 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Pullagura Sri Ramulu N SRN Buaas Bill B Gray Nichelle N Krening Lindsey C LC Srivastava Anuj A Braun Robert E RE
Genetics 20180221 4
Several <i>in vitro</i> studies have suggested that canonical microRNA (miRNA) biogenesis requires the DICER cofactors TARBP2 and PRKRA for processing of pre-miRNAs to mature miRNAs. To investigate the roles of TARBP2 and PRKRA in miRNA biogenesis <i>in vivo</i>, and to determine possible functional redundancy, we first compared the phenotypes of <i>Tarbp2</i> and <i>Prkra</i> single and double mutants. In contrast to <i>Dicer <sup>-/-</sup></i> embryos, which die by embryonic day 7.5 (E7.5), si ...[more]