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Lobophytones O-T, new biscembranoids and cembranoid from soft coral Lobophytum pauciflorum.

ABSTRACT: Chemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation of five new biscembranoids named lobophytones O-S (1-5) and a new "monomeric" cembrane lobophytone T (6). The structures of the new compounds were elucidated by interpretation of 1D and 2D NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic data in association with MS and IR data. Lobophytone Q showed significant inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) release in mouse peritoneal macrophages, while lobophytones Q and T showed inhibitory activities against the bacteria S. aureus and S. pneumoniae.

SUBMITTER: Yan P

PROVIDER: S-EPMC2996179 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature

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Lobophytones O-T, new biscembranoids and cembranoid from soft coral Lobophytum pauciflorum.

Yan Pengcheng P Deng Zhiwei Z van Ofwegen Leen L Proksch Peter P Lin Wenhan W

Marine drugs 20101110 11

Chemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation of five new biscembranoids named lobophytones O-S (1-5) and a new "monomeric" cembrane lobophytone T (6). The structures of the new compounds were elucidated by interpretation of 1D and 2D NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic data in association with MS and IR data. Lobophytone Q showed significant inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) release in mouse peritone ...[more]

PMID: 21139847

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