New Hydroquinone Monoterpenoid and Cembranoid-Related Metabolites from the Soft Coral Sarcophyton tenuispiculatum.

ABSTRACT: Chemical investigation of the marine soft coral Sarcophyton tenuispiculatum resulted in the isolation of a 1,4-dihydrobenzoquinone, sarcotenuhydroquinone (1), three new cembranoids, sarcotenusenes A?C (2?4), and ten previously reported metabolites 5-14. The chemical structures of all isolated metabolites were determined by detailed spectroscopic analyses. In biological assays, anti-inflammatory, cytotoxic, and peroxisome proliferator-activated receptor ? (PPAR-?) transcription factor assays of all compounds were performed. None of the isolated compounds were found to exhibit activity in the PPAR-? transcription factor assay. The anti-inflammatory assays showed that (+)-7?,8?-dihydroxydeepoxysarcophine (13) inhibited the production of IL-1? to 56 ± 1% at a concentration of 30 µM in lipopolysaccharide (LPS)-stimulated J774A.1 macrophage cells. In addition, 1 and 2 were found to exhibit cytotoxicity towards a panel of cancer cell lines.

SUBMITTER: Huang TY 

PROVIDER: S-EPMC7823492 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature