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Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum.

ABSTRACT: Ten new cembrane-based diterpenes, locrassumins A-G (1-7), (-)-laevigatol B (8), (-)-isosarcophine (9), and (-)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11-18). The structures of the new compounds were determined by extensive spectroscopic analysis and by comparison with previously reported data. Locrassumin C (3) possesses an unprecedented tetradecahydrobenzo[3,4]cyclobuta[1,2][8]annulene ring system. Compounds 1, 7, 12, 13, and 17 exhibited moderate inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC50 values of 8-24 ?M.

SUBMITTER: Zhao M

PROVIDER: S-EPMC4926070 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum.

Zhao Min M Cheng Shimiao S Yuan Weiping W Xi Yiyuan Y Li Xiubao X Dong Jianyong J Huang Kexin K Gustafson Kirk R KR Yan Pengcheng P

Marine drugs 20160603 6

Ten new cembrane-based diterpenes, locrassumins A-G (1-7), (-)-laevigatol B (8), (-)-isosarcophine (9), and (-)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11-18). The structures of the new compounds were determined by extensive spectroscopic analysis and by comparison with previously reported data. Locrassumin C (3) possesses an unprecedented tetradecahydrobenzo[3,4]cyclobut ...[more]

PMID: 27271640

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