Ontology highlight
ABSTRACT:
SUBMITTER: Hazemi P
PROVIDER: S-EPMC2996585 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Hazemi Parastoo P Tzotzos Susan J SJ Fischer Bernhard B Andavan Gowri Shankar Bagavananthem GS Fischer Hendrik H Pietschmann Helmut H Lucas Rudolf R Lemmens-Gruber Rosa R
Journal of medicinal chemistry 20101027 22
The amiloride-sensitive epithelial sodium channel (ENaC) plays a prominent role in sodium uptake from alveolar fluid and is the major component in alveolar fluid clearance in normal and diseased lungs. The lectin-like domain of TNF-α has been shown to activate amiloride-sensitive sodium uptake in type II alveolar epithelial cells. Therefore, several synthetic peptides that mimic the lectin-like domain of TNF-α (TIP) were synthesized and their ability to enhance sodium current through ENaC was st ...[more]