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? ENaC: a novel divergent amiloride-inhibitable sodium channel.

ABSTRACT: The fourth subunit of the epithelial sodium channel, termed delta subunit (? ENaC), was cloned in human and monkey. Increasing evidence shows that this unique subunit and its splice variants exhibit biophysical and pharmacological properties that are divergent from those of ? ENaC channels. The widespread distribution of epithelial sodium channels in both epithelial and nonepithelial tissues implies a range of physiological functions. The altered expression of SCNN1D is associated with numerous pathological conditions. Genetic studies link SCNN1D deficiency with rare genetic diseases with developmental and functional disorders in the brain, heart, and respiratory systems. Here, we review the progress of research on ? ENaC in genomics, biophysics, proteomics, physiology, pharmacology, and clinical medicine.

SUBMITTER: Ji HL

PROVIDER: S-EPMC3532584 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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δ ENaC: a novel divergent amiloride-inhibitable sodium channel.

Ji Hong-Long HL Zhao Run-Zhen RZ Chen Zai-Xing ZX Shetty Sreerama S Idell Steven S Matalon Sadis S

American journal of physiology. Lung cellular and molecular physiology 20120914 12

The fourth subunit of the epithelial sodium channel, termed delta subunit (δ ENaC), was cloned in human and monkey. Increasing evidence shows that this unique subunit and its splice variants exhibit biophysical and pharmacological properties that are divergent from those of α ENaC channels. The widespread distribution of epithelial sodium channels in both epithelial and nonepithelial tissues implies a range of physiological functions. The altered expression of SCNN1D is associated with numerous ...[more]

PMID: 22983350

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