Ontology highlight
ABSTRACT:
SUBMITTER: Li F
PROVIDER: S-EPMC2996867 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Cell stem cell 20101001 4
The molecular mechanisms involved in the derivation of induced pluripotent stem cells (iPSCs) from differentiated cells are poorly understood. Here we report that caspases 3 and 8, two proteases associated with apoptotic cell death, play critical roles in induction of iPSCs from human fibroblasts. Activation of caspases 3 and 8 occurs soon after transduction of iPSC-inducing transcription factors. Oct-4, a key iPSC transcription factor, is responsible for the activation. Inhibition of caspase 3 ...[more]