Ontology highlight
ABSTRACT:
SUBMITTER: Kinjyo I
PROVIDER: S-EPMC2997140 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Kinjyo Ichiko I Gordon Scott M SM Intlekofer Andrew M AM Dowdell Kennichi K Mooney Erin C EC Caricchio Roberto R Grupp Stephan A SA Teachey David T DT Rao V Koneti VK Lindsten Tullia T Reiner Steven L SL
Journal of immunology (Baltimore, Md. : 1950) 20101112 12
A hallmark of autoimmune lymphoproliferative syndrome (ALPS), caused by mutation of the Fas death receptor, is massive lymphadenopathy from aberrant expansion of CD4(-)CD8(-) (double-negative [DN]) T cells. Eomesodermin (Eomes) is a member of the T-box family of transcription factors and plays critical roles in effector cell function and memory cell fitness of CD8(+) T lymphocytes. We provide evidence in this study that DN T cells exhibit dysregulated expression of Eomes in humans and mice with ...[more]