Ontology highlight
ABSTRACT:
SUBMITTER: Yogurtcu ON
PROVIDER: S-EPMC3000483 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Yogurtcu Osman N ON Wolgemuth Charles W CW Sun Sean X SX
Biophysical journal 20101201 12
α-Helical coiled coils (CCs) are ubiquitous tertiary structural domains that are often found in mechanoproteins. CCs have mechanical rigidity and are often involved in force transmission between protein domains. Although crystal structures of CCs are available, information about their conformational flexibility is limited. The role of hydrophobic interactions in determining the CC conformation is not clear. In this work we examined the mechanical responses of typical CCs and constructed a coarse ...[more]