Ontology highlight
ABSTRACT:
SUBMITTER: Xu Z
PROVIDER: S-EPMC3000998 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Xu Zhenjie Z Vagnarelli Paola P Ogawa Hiromi H Samejima Kumiko K Earnshaw William C WC
The Journal of biological chemistry 20101018 51
INCENP, Borealin, Survivin, and Aurora B kinase comprise the chromosomal passenger complex, an essential regulator of mitotic events. INCENP (inner centromere protein) binds and activates Aurora B through a feedback loop involving phosphorylation of a Thr-Ser-Ser (TSS) motif near the INCENP C terminus. Here, we have examined the role of the TSS motif in vertebrate cells using an DT40 INCENP(ON/OFF) conditional knock-out cell line in which mutants are expressed in the absence of wild-type INCENP. ...[more]