Ontology highlight
ABSTRACT:
SUBMITTER: Hinits Y
PROVIDER: S-EPMC3001336 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Hinits Yaniv Y Osborn Daniel P S DP Carvajal Jaime J JJ Rigby Peter W J PW Hughes Simon M SM
Gene expression patterns : GEP 20070615 7
Mrf4 (Myf6) is a member of the basic helix-loop-helix (bHLH) myogenic regulatory transcription factor (MRF) family, which also contains Myod, Myf5 and myogenin. Mrf4 is implicated in commitment of amniote cells to skeletal myogenesis and is also abundantly expressed in many adult muscle fibres. The specific role of Mrf4 is unclear both because mrf4 null mice are viable, suggesting redundancy with other MRFs, and because of genetic interactions at the complex mrf4/myf5 locus. We report the clonin ...[more]