Ontology highlight
ABSTRACT:
SUBMITTER: Hain D
PROVIDER: S-EPMC3002974 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Hain Daniel D Bettencourt Brian R BR Okamura Katsutomo K Csorba Tibor T Meyer Wibke W Jin Zhigang Z Biggerstaff Jason J Siomi Haruhiko H Hutvagner Gyorgy G Lai Eric C EC Welte Michael M Müller H-Arno J HA
PloS one 20101217 12
The Drosophila argonaute2 (ago2) gene plays a major role in siRNA mediated RNA silencing pathways. Unlike mammalian Argonaute proteins, the Drosophila protein has an unusual amino-terminal domain made up largely of multiple copies of glutamine-rich repeats (GRRs). We report here that the ago2 locus produces an alternative transcript that encodes a putative short isoform without this amino-terminal domain. Several ago2 mutations previously reported to be null alleles only abolish expression of th ...[more]