Ontology highlight
ABSTRACT:
SUBMITTER: Fasano S
PROVIDER: S-EPMC3003069 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Fasano Stefania S Bezard Erwan E D'Antoni Angela A Francardo Veronica V Indrigo Marzia M Qin Li L Doveró Sandra S Cerovic Milica M Cenci M Angela MA Brambilla Riccardo R
Proceedings of the National Academy of Sciences of the United States of America 20101129 50
L-dopa-induced dyskinesia (LID) is a common debilitating complication of dopamine replacement therapy in Parkinson's disease. Recent evidence suggests that LID may be linked causally to a hyperactivation of the Ras-ERK signaling cascade in the basal ganglia. We set out to determine whether specific targeting of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1), a brain-specific activator of the Ras-ERK pathway, may provide a therapy for LID. On the rodent abnormal involuntary movements scale, ...[more]