Ontology highlight
ABSTRACT:
SUBMITTER: Sukumaran B
PROVIDER: S-EPMC3005019 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Cellular microbiology 20100827 1
Anaplasma phagocytophilum causes human granulocytic anaplasmosis, one of the most common tick-borne diseases in North America. This unusual obligate intracellular pathogen selectively persists within polymorphonuclear leucocytes. In this study, using the yeast surrogate model we identified an A. phagocytophilum virulence protein, AptA (A. phagocytophilum toxin A), that activates mammalian Erk1/2 mitogen-activated protein kinase. This activation is important for A. phagocytophilum survival within ...[more]