Ontology highlight
ABSTRACT:
SUBMITTER: Herath A
PROVIDER: S-EPMC3005611 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Organic letters 20101021 22
The first one-step, continuous flow synthesis of pyrrole-3-carboxylic acids directly from tert-butyl acetoacetates, amines, and 2-bromoketones is reported. The HBr generated as a byproduct in the Hantzsch reaction was utilized in the flow method to hydrolyze the t-butyl esters in situ to provide the corresponding acids in a single microreactor. The protocol was used in the multistep synthesis of pyrrole-3-carboxamides, including two CB1 inverse agonists, directly from commercially available star ...[more]