Ontology highlight
ABSTRACT:
SUBMITTER: Zhao C
PROVIDER: S-EPMC3007156 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Zhao Chen C Yasumura Douglas D Li Xiyan X Matthes Michael M Lloyd Marcia M Nielsen Gregory G Ahern Kelly K Snyder Michael M Bok Dean D Dunaief Joshua L JL LaVail Matthew M MM Vollrath Douglas D
The Journal of clinical investigation 20101206 1
Retinal pigment epithelial (RPE) cell dysfunction plays a central role in various retinal degenerative diseases, but knowledge is limited regarding the pathways responsible for adult RPE stress responses in vivo. RPE mitochondrial dysfunction has been implicated in the pathogenesis of several forms of retinal degeneration. Here we have shown that postnatal ablation of RPE mitochondrial oxidative phosphorylation in mice triggers gradual epithelium dedifferentiation, typified by reduction of RPE-c ...[more]