Ontology highlight
ABSTRACT:
SUBMITTER: Gaglia JL
PROVIDER: S-EPMC4343112 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Gaglia Jason L JL Harisinghani Mukesh M Aganj Iman I Wojtkiewicz Gregory R GR Hedgire Sandeep S Benoist Christophe C Mathis Diane D Weissleder Ralph R
Proceedings of the National Academy of Sciences of the United States of America 20150203 7
The inability to visualize the initiation and progression of type-1 diabetes (T1D) noninvasively in humans is a major research and clinical stumbling block. We describe an advanced, exportable method for imaging the pancreatic inflammation underlying T1D, based on MRI of the clinically approved magnetic nanoparticle (MNP) ferumoxytol. The MNP-MRI approach, which reflects nanoparticle uptake by macrophages in the inflamed pancreatic lesion, has been validated extensively in mouse models of T1D an ...[more]