Ontology highlight
ABSTRACT:
SUBMITTER: Pilon AM
PROVIDER: S-EPMC3208289 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Pilon Andre M AM Ajay Subramanian S SS Kumar Swathi Ashok SA Steiner Laurie A LA Cherukuri Praveen F PF Wincovitch Stephen S Anderson Stacie M SM Mullikin James C JC Gallagher Patrick G PG Hardison Ross C RC Margulies Elliott H EH Bodine David M DM
Blood 20110906 17
Erythropoiesis is dependent on the activity of transcription factors, including the erythroid-specific erythroid Kruppel-like factor (EKLF). ChIP followed by massively parallel sequencing (ChIP-Seq) is a powerful, unbiased method to map trans-factor occupancy. We used ChIP-Seq to study the interactome of EKLF in mouse erythroid progenitor cells and more differentiated erythroblasts. We correlated these results with the nuclear distribution of EKLF, RNA-Seq analysis of the transcriptome, and the ...[more]