Ontology highlight
ABSTRACT:
SUBMITTER: Rawls KA
PROVIDER: S-EPMC3009555 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Rawls Katherine A KA Grundner Christoph C Ellman Jonathan A JA
Organic & biomolecular chemistry 20100719 18
The design and synthesis of new inhibitor analogues for the Mycobacterium tuberculosis (Mtb) phosphatase PtpB is described. Analogues were synthesized by incorporation of two common and effective phosphate mimetics, the isothiazolidinone (IZD) and the difluoromethylphosphonic acid (DFMP). The basic scaffold of the inhibitor was identified from structure-activity relationships established for a previously published isoxazole inhibitor, while the phosphate mimetics were chosen based on their prove ...[more]