Ontology highlight
ABSTRACT:
SUBMITTER: Krivtsov AV
PROVIDER: S-EPMC2591932 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Krivtsov Andrei V AV Feng Zhaohui Z Lemieux Madeleine E ME Faber Joerg J Vempati Sridhar S Sinha Amit U AU Xia Xiaobo X Jesneck Jonathan J Bracken Adrian P AP Silverman Lewis B LB Kutok Jeffery L JL Kung Andrew L AL Armstrong Scott A SA
Cancer cell 20081101 5
We created a mouse model wherein conditional expression of an Mll-AF4 fusion oncogene induces B precursor acute lymphoblastic (ALL) or acute myeloid leukemias (AML). Gene expression profile analysis of the ALL cells demonstrated significant overlap with human MLL-rearranged ALL. ChIP-chip analysis demonstrated histone H3 lysine 79 (H3K79) methylation profiles that correlated with Mll-AF4-associated gene expression profiles in murine ALLs and in human MLL-rearranged leukemias. Human MLL-rearrange ...[more]