Ontology highlight
ABSTRACT:
SUBMITTER: Brooks CF
PROVIDER: S-EPMC3013619 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Brooks Carrie F CF Johnsen Hanne H van Dooren Giel G GG Muthalagi Mani M Lin San San SS Bohne Wolfgang W Fischer Karsten K Striepen Boris B
Cell host & microbe 20091231 1
Apicomplexa are unicellular eukaryotic pathogens that carry a vestigial algal endosymbiont, the apicoplast. The physiological function of the apicoplast and its integration into parasite metabolism remain poorly understood and at times controversial. We establish that the Toxoplasma apicoplast membrane-localized phosphate translocator (TgAPT) is an essential metabolic link between the endosymbiont and the parasite cytoplasm. TgAPT is required for fatty acid synthesis in the apicoplast, but this ...[more]