Ontology highlight
ABSTRACT:
SUBMITTER: Qu H
PROVIDER: S-EPMC3014449 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Qu Hongchang H Magotti Paola P Ricklin Daniel D Wu Emilia L EL Kourtzelis Ioannis I Wu You-Qiang YQ Kaznessis Yiannis N YN Lambris John D JD
Molecular immunology 20101109 4
Compstatin is a 13-residue disulfide-bridged peptide that inhibits a key step in the activation of the human complement system. Compstatin and its derivatives have shown great promise for the treatment of many clinical disorders associated with unbalanced complement activity. To obtain more potent compstatin analogues, we have now performed an N-methylation scan of the peptide backbone and amino acid substitutions at position 13. One analogue (Ac-I[CVW(Me)QDW-Sar-AHRC](NMe)I-NH(2)) displayed a 1 ...[more]