Ontology highlight
ABSTRACT:
SUBMITTER: Redman LM
PROVIDER: S-EPMC5886711 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Redman Leanne M LM Smith Steven R SR Burton Jeffrey H JH Martin Corby K CK Il'yasova Dora D Ravussin Eric E
Cell metabolism 20180322 4
Calorie restriction (CR) is a dietary intervention with potential benefits for healthspan improvement and lifespan extension. In 53 (34 CR and 19 control) non-obese adults, we tested the hypothesis that energy expenditure (EE) and its endocrine mediators are reduced with a CR diet over 2 years. Approximately 15% CR was achieved over 2 years, resulting in an average 8.7 kg weight loss, whereas controls gained 1.8 kg. In the CR group, EE measured over 24 hr or during sleep was approximately 80-120 ...[more]