Ontology highlight
ABSTRACT:
SUBMITTER: Wingo TS
PROVIDER: S-EPMC3021799 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Wingo Thomas S TS Rosen Ami A Cutler David J DJ Lah James J JJ Levey Allan I AI
Neurobiology of aging 20101013 1
Paraoxonase-1 (PON1) is a serum arylsulfatase that metabolizes organophosphate pesticides and protects low-density lipoprotein from oxidation. Case-control studies of PON1 genetic variants in Alzheimer's disease (AD) and Parkinson's disease (PD) have revealed some positive albeit inconsistent associations with 2 PON1 coding polymorphisms: Q192R (rs662) and L55M (rs854560). Because AD and PD exist along a spectrum of disorders with shared epidemiologic, clinical, and pathologic features, here we ...[more]