Ontology highlight
ABSTRACT:
SUBMITTER: Benjamin AM
PROVIDER: S-EPMC3021872 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Benjamin Ashlee M AM Suchindran Sunil S Pearce Kaela K Rowell Jennifer J Lien Lillian F LF Guyton John R JR McCarthy Jeanette J JJ
Journal of obesity 20101226
Obesity is an increasingly prevalent and severe health concern with a substantial heritable component and marked sex differences. We sought to determine if the effect of genetic variants also differed by sex by performing a genome-wide association study modeling the effect of genotype-by-sex interaction on obesity phenotypes. Genotype data from individuals in the Framingham Heart Study Offspring cohort were analyzed across five exams. Although no variants showed genome-wide significant gene-by-s ...[more]