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Gene by sex interaction for measures of obesity in the framingham heart study.


ABSTRACT: Obesity is an increasingly prevalent and severe health concern with a substantial heritable component and marked sex differences. We sought to determine if the effect of genetic variants also differed by sex by performing a genome-wide association study modeling the effect of genotype-by-sex interaction on obesity phenotypes. Genotype data from individuals in the Framingham Heart Study Offspring cohort were analyzed across five exams. Although no variants showed genome-wide significant gene-by-sex interaction in any individual exam, four polymorphisms displayed a consistent BMI association (P-values .00186 to .00010) across all five exams. These variants were clustered downstream of LYPLAL1, which encodes a lipase/esterase expressed in adipose tissue, a locus previously identified as having sex-specific effects on central obesity. Primary effects in males were in the opposite direction from females and were replicated in Framingham Generation 3. Our data support a sex-influenced association between genetic variation at the LYPLAL1 locus and obesity-related traits.

SUBMITTER: Benjamin AM 

PROVIDER: S-EPMC3021872 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Gene by sex interaction for measures of obesity in the framingham heart study.

Benjamin Ashlee M AM   Suchindran Sunil S   Pearce Kaela K   Rowell Jennifer J   Lien Lillian F LF   Guyton John R JR   McCarthy Jeanette J JJ  

Journal of obesity 20101226


Obesity is an increasingly prevalent and severe health concern with a substantial heritable component and marked sex differences. We sought to determine if the effect of genetic variants also differed by sex by performing a genome-wide association study modeling the effect of genotype-by-sex interaction on obesity phenotypes. Genotype data from individuals in the Framingham Heart Study Offspring cohort were analyzed across five exams. Although no variants showed genome-wide significant gene-by-s  ...[more]

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