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Cutting edge: Intrinsic programming of thymic ??T cells for specific peripheral tissue localization.

ABSTRACT: Various innate-like T cell subsets preferentially reside in specific epithelial tissues as the first line of defense. However, mechanisms regulating their tissue-specific development are poorly understood. Using the prototypical skin intraepithelial ??T cells (sIELs) as a model, we show in this study that a TCR-mediated selection plays an important role in promoting acquisition of a specific skin-homing property by fetal thymic sIEL precursors for their epidermal location, and the skin-homing potential is intrinsically programmed even before the selection. In addition, once localized in the skin, the sIEL precursors develop into sIELs without the requirement of further TCR-ligand interaction. These studies reveal that development of the tissue-specific lymphocytes is a hard-wired process that targets them to specific tissues for proper functions.

SUBMITTER: Jin Y

PROVIDER: S-EPMC3023158 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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Cutting edge: Intrinsic programming of thymic γδT cells for specific peripheral tissue localization.

Jin Yan Y Xia Mingcan M Saylor Christina M CM Narayan Kavitha K Kang Joonsoo J Wiest David L DL Wang Yanming Y Xiong Na N

Journal of immunology (Baltimore, Md. : 1950) 20101110 12

Various innate-like T cell subsets preferentially reside in specific epithelial tissues as the first line of defense. However, mechanisms regulating their tissue-specific development are poorly understood. Using the prototypical skin intraepithelial γδT cells (sIELs) as a model, we show in this study that a TCR-mediated selection plays an important role in promoting acquisition of a specific skin-homing property by fetal thymic sIEL precursors for their epidermal location, and the skin-homing po ...[more]

PMID: 21068400

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