Ontology highlight
ABSTRACT:
SUBMITTER: Deets KA
PROVIDER: S-EPMC4779721 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Deets Katherine A KA Berkley Amy M AM Bergsbaken Tessa T Fink Pamela J PJ
Journal of immunology (Baltimore, Md. : 1950) 20160212 6
The youngest peripheral T cells (recent thymic emigrants [RTEs]) are functionally distinct from naive T cells that have completed postthymic maturation. We assessed the RTE memory response and found that RTEs produced less granzyme B than their mature counterparts during infection but proliferated more and, therefore, generated equivalent target killing in vivo. Postinfection, RTE numbers contracted less dramatically than those of mature T cells, but RTEs were delayed in their transition to cent ...[more]