Ontology highlight
ABSTRACT:
SUBMITTER: Joller N
PROVIDER: S-EPMC3128994 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20110103 3
Costimulatory molecules regulate the functional outcome of T cell activation, and disturbance of the balance between activating and inhibitory signals results in increased susceptibility to infection or the induction of autoimmunity. Similar to the well-characterized CD28/CTLA-4 costimulatory pathway, a newly emerging pathway consisting of CD226 and T cell Ig and ITIM domain (TIGIT) has been associated with susceptibility to multiple autoimmune diseases. In this study, we examined the role of th ...[more]