Ontology highlight
ABSTRACT:
SUBMITTER: de Lencastre A
PROVIDER: S-EPMC3023310 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Current biology : CB 20101202 24
<h4>Background</h4>aging is under genetic control in C. elegans, but the mechanisms of life-span regulation are not completely known. MicroRNAs (miRNAs) regulate various aspects of development and metabolism, and one miRNA has been previously implicated in life span.<h4>Results</h4>here we show that multiple miRNAs change expression in C. elegans aging, including novel miRNAs, and that mutations in several of the most upregulated miRNAs lead to life-span defects. Some act to promote normal life ...[more]