Modulation of RNA polymerase activity through the trigger loop folding.
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ABSTRACT:
SUBMITTER: Miropolskaya N
PROVIDER: S-EPMC3023635 | biostudies-literature | 2010 Sep-Oct
REPOSITORIES: biostudies-literature
Publications
Modulation of RNA polymerase activity through the trigger loop folding.
Miropolskaya Nataliya N Nikiforov Vadim V Klimasauskas Saulius S Artsimovitch Irina I Kulbachinskiy Andrey A
Transcription 20100901 2
Folding of the trigger loop of RNA polymerase promotes nucleotide addition through creating a closed, catalytically competent conformation of the active center. Here, we discuss the impact of adjacent RNA polymerase elements, including the F loop and the jaw domain, as well as external regulatory factors on the trigger loop folding and catalysis. ...[more]
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Project description:[This corrects the article DOI: 10.1371/journal.pgen.1006321.].
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