Ontology highlight
ABSTRACT:
SUBMITTER: Santiago-Tirado FH
PROVIDER: S-EPMC3025538 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Santiago-Tirado Felipe H FH Legesse-Miller Aster A Schott Daniel D Bretscher Anthony A
Developmental cell 20110101 1
Cell polarity involves transport of specific membranes and macromolecules at the right time to the right place. In budding yeast, secretory vesicles are transported by the myosin-V Myo2p to sites of cell growth. We show that phosphatidylinositol 4-phosphate (PI4P) is present in late secretory compartments and is critical for their association with, and transport by, Myo2p. Further, the trans-Golgi network Rab Ypt31/32p and secretory vesicle Rab Sec4p each bind directly, but distinctly, to Myo2p, ...[more]