A novel method for the genome-wide high resolution analysis of DNA damage.
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ABSTRACT:
SUBMITTER: Teng Y
PROVIDER: S-EPMC3025580 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Publications
A novel method for the genome-wide high resolution analysis of DNA damage.
Teng Yumin Y Bennett Mark M Evans Katie E KE Zhuang-Jackson Huayun H Higgs Andy A Reed Simon H SH Waters Raymond R
Nucleic acids research 20101109 2
DNA damage occurs via endogenous and exogenous genotoxic agents and compromises a genome's integrity. Knowing where damage occurs within a genome is crucial to understanding the repair mechanisms which protect this integrity. This paper describes a new development based on microarray technology which uses ultraviolet light induced DNA damage as a paradigm to determine the position and frequency of DNA damage and its subsequent repair throughout the entire yeast genome. ...[more]
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