Ontology highlight
ABSTRACT:
SUBMITTER: Doitsh G
PROVIDER: S-EPMC4047036 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Doitsh Gilad G Galloway Nicole L K NL Geng Xin X Yang Zhiyuan Z Monroe Kathryn M KM Zepeda Orlando O Hunt Peter W PW Hatano Hiroyu H Sowinski Stefanie S Muñoz-Arias Isa I Greene Warner C WC
Nature 20140101 7484
The pathway causing CD4 T-cell death in HIV-infected hosts remains poorly understood although apoptosis has been proposed as a key mechanism. We now show that caspase-3-mediated apoptosis accounts for the death of only a small fraction of CD4 T cells corresponding to those that are both activated and productively infected. The remaining over 95% of quiescent lymphoid CD4 T cells die by caspase-1-mediated pyroptosis triggered by abortive viral infection. Pyroptosis corresponds to an intensely inf ...[more]